Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1)
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Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1)
Dear Editor, In the February 2014 issue of the Journal of Histochemistry & Cytochemistry, Tόth and colleagues published a report on Transient Receptor Potential Vanilloid 1 (TRPV1) expression and function in the rat vascular system (Tόth et al. 2014). The authors found that several commercially available anti-TRPV1 antibodies were not selective for TRPV1, and identified two that were considered...
متن کاملTransient Receptor Potential Vanilloid 1
Background and structure Transient receptor potential vanilloid receptor 1 (TRPV1) is one of 6 members of the subfamily of vanilloid receptors that belongs to the family of transient receptor potential (TRP) channels. TRP channels are an intrinsic part of the mammalian sensory system responding to a broad range of stimuli such as temperature, touch, pain, osmolarity, pheromones, and taste (8). ...
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BACKGROUND Blast-related ocular injuries sustained by military personnel have led to rigorous efforts to elucidate the effects of blast exposure on neurosensory function. Recent studies have provided some insight into cognitive and visual deficits sustained following blast exposure; however, limited data are available on the effects of blast on pain and inflammatory processes. Investigation of ...
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Introduction: Nucleus cuneiformis (NCF), as part of descending pain inhibitory system, cooperates with periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) in supraspinal modulation of pain. Cannabinoids have analgesic effects in the PAG, RVM and NCF. The transient receptor potential vanilloid type 1(TRPV1) can be activated by anandamide and WIN55,212-2 as a cannabinoid receptor ago...
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BACKGROUND The transient receptor potential vanilloid receptor 1, TRPV1 [previously termed the capsaicin or vanilloid receptor 1 (VR1)] is a nonselective cation channel that has been cloned and is expressed predominantly in sensory neurons. TRPV1 is activated by protons as well as capsaicin. Despite extensive research, the physiological function of TRPV1 in the gastrointestinal tract and other ...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2015
ISSN: 0022-1554,1551-5044
DOI: 10.1369/0022155415581014